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Zenit PRO

The information to be found in this section is intended for the exclusive use of healthcare professionals.



More needles
for higher speed Two dispensing needles and one aspiration needle increase preparation speed
Multiple run
Up to 18 slides can be simultaneously loaded to be processed. 
Wash station
A wash station ensures both internal and external cleaning of the three needles eliminating carryover
Automated coverslipping and mounting
The system automatically mounts each processed slide. A suction pad places the coverslip and seals the slide, avoiding the formation of air bubbles
Automated slide delivery
A precision clamp delivers the mounted slide onto the microscope precision stage for automated scanning of each well
Automated slide reader
The motorized microscope drives to the substrate positions, autofocuses and scan each well
Slide parking rack
After termination of the reading procedure, a precision clamp delivers the slide into a parking rack to await removal by the operator. Up to 18 slides can be stacked in this area
In-built touch screen monitor
On-board digital archive
Bar code readers for full traceability of sample and slide

The Zenit brand: a leading presence with complete coverage in the autoimmunity field

Autoimmunity has been our focus since 1998.
Extensive research and a proven track record of accuracy and reliability have allowed us to expand our early experience into an international organization with a comprehensive offering including IFA, ELISA, CLIA, microarray, genetic testing, biomonitoring, with the smallest instrument range coupled with the widest possible array of antigens, both human recombinant and human purified, to cover all diagnostic needs. Our goal is to continue developing solutions for the clinic and laboratory that improve the diagnosis, prognosis, monitoring and treatment of autoimmune diseases.

Evolving scenarios and innovative perspectives

Autoimmune diseases and the role of IFA

The impact of autoimmune diseases has grown exponentially both from a clinical and a diagnostic point of view over the past few decades. The knowledge of the pathogenic mechanisms underlying autoimmune diseases contributed to identify new autoantibodies and new diagnostic/prognostic assays have been developed.

Antinuclear antibodies (ANA) are important elements in the diagnosis of a variety of autoimmune diseases, especially ANA-associated rheumatic diseases (AARD), and indirect immunofluorescence (IFA), although it has been in use for over 50 years, is still the recommended method to screen for ANAs.

Specifically, according to the recommendations of the American College of Rheumatology, ANA Task Force, the IFA assay on human epidermoid laryngeal carcinoma (HEp-2) cells represents the gold standard for ANA testing.

Nevertheless, performing ANA testing with IFA is time-consuming, labor intensive and burdened by some unfavorable features, such as the need for expert reading by skilled operators, a high rate of subjectivity and the low degree of standardization.

Laboratories that are testing on autoimmunity have made strides in automation over the past decade; technological solutions have been developed and automated reading systems have been made more and more reliable to achieve improved sensitivity and specificity, to obtain reproducible results and guarantee analytical precision.

In order to further improve standardization of the whole IFA procedure, A.Menarini Diagnostics has developed Zenit PRO, the brand new all-in-one system for the total automation of IFA: not only are reading and interpretation automatically performed but also the slide preparation, thus reducing the effects caused by less trained personnel and differences which might show up in different laboratories.

With Zenit PRO you will achieve a new level of standardization, increase efficiency and productivity with a remarkable impact on the overall laboratory management for improved health outcomes.

A generation ahead in IFA automation

The evolution of standardization

Zenit PRO is the new high-performance A.Menarini Diagnostics fully automated system which streamlines the whole IFA protocol, from slide processing to reading and interpretation of results.
The system integrates an enhanced module that ensures the complete slide preparation, from serum dilution to coverslipping, with an on-board reading unit which provides unparalleled accuracy and allows automated whole well digitization for a better interpretation of Zenit IFA tests.

What makes Zenit PRO different are the image autofocusing technology, the software algorithms for IFA detection and pattern recognition, run-time, types of recognized ANA IFA patterns, and its ability to analyze different kinds of IFA substrate.

Thus, Zenit PRO is able to overcome the drawbacks of manual ANA IFA analysis, and it efficiently contributes to the harmonization of the HEp-2 IFA analysis.

Main features and benefits

  • Automated IFA slide preparation and coverslip mounting
  • Walkaway process
  • Whole well scanning
  • Navigable well
  • High throughput
  • Reduction of intra- and inter-laboratory variability
  • Full traceability
  • Reduction of operating costs